PAOK Thessaloniki (Greece) vs. Metalist Kharkiv (Ukraine)
PSV Eindhoven (Netherlands) vs. Zulte Waregem (Belgium)
Lyon (France) vs. Grasshoppers (Switzerland)
Champions Route=
FC Basel (Switzerland) vs. Gyor (Hungary) or Maccabi Tel Aviv (Israel)
Sligo Rovers (Ireland) or Molde (Norway) vs. The New Saints (Wales) or Legia Warsaw (Poland)
Slovan Bratislava (Slovakia) or Ludogorets Razgrad (Bulgaria) vs. Shirak (Armenia) or Partizan Belgrade (Serbia)
Dinamo Tbilisi (Georgia) or EB/Streymur (Faeroe Islands) vs. Steaua Bucharest (Romania) or Vardar (Macedonia)
APOEL (Cyprus) vs. Birkirkara (Malta) or Maribor (Slovenia)
Celtic (Scotland) or Cliftonville (Northern Ireland) vs. Elfsborg (Sweden) or Daugava Daugavpils (Latvia)
BATE Borisov (Belarus) or Shakhter Karagandy (Kazakhstan) vs. Neftchi Baku (Azerbaijan) or Skenderbeu Korce (Albania)
Austria Vienna (Austria) vs. Ekranas (Lithuania) or FH Hafnarfjordur (Iceland)
HJK Helsinki (Finland) or Nomme Kalju (Estonia) vs. Viktoria Plzen (Czech Republic) or Zeljeznicar (Bosnia-Herzegovina)
Fola Esch (Luxembourg) or Dinamo Zagreb (Croatia) vs. Sheriff Tiraspol (Moldova) or Sutjeska Niksic (Montenegro)
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x-Fenerbahce enters pending outcome of appeal against UEFA ban for match-fixing