Ryan Nelsen, Winston Reid, Rory Fallon and Tony Lochhead are the All Whites stalwarts expected to be missing on the first leg of The Road to Rio next week.
That is when coach Ricki Herbert names his All Whites squad for the Oceania Nations Cup in June, as well as the two-match tour to the United States later this month. Herbert will take 20 players to the US for the games against El Salvador and Honduras and then a 23-man squad to the Solomon Islands.
It is believed that Nelsen and Fallon will be unavailable for the American leg while Lochhead will also miss the trip as he is getting married. West Ham defender Reid is also in doubt, as he will be playing in England's Championship playoff final just three days before the El Salvador match in Dallas.
The rest of the squad from February's loss to Jamaica should figure at the Nations Cup, though Scott Basalaj faces a battle with Jake Gleeson and Stefan Marinovic for the third goalkeeping spot behind Mark Paston and Glen Moss.
The defence will feature Reid, Nelsen, Tommy Smith, Ben Sigmund, Lochhead and Ivan Vicelich, although the Auckland City veteran may be used in a defensive midfield role, given the retirement of Tim Brown and the continued unavailability of Simon Elliott.