With all this in mind, both the Springbok and Puma squads will be the best place to look for points this weekend.
However, there are always exceptions to the rule and players that seem to perform no matter the occasion.
Dan Carter and Bernard Foley are sure to have plenty of kicking opportunities while Ma'a Nonu and Jerome Kaino look to be putting everything in to what will be their final flings and are great selections.
Rob Simmons, Richie McCaw and Scott Fardy have also been huge at the pointy end of this game.
Before setting your squads, please make note of the below changes to sides and keep an eye on the Herald Rugby site for any last-minute injury news.
Good luck to all those competing for the overall Fantasy International Rugby title as well as those who aim to top their groups. Below is my team to select for the round ahead, based on career stats, recent form and the match up.
DR STATS XV
Front Row
Dane Coles, New Zealand, $72,800
Bismarck du Plessis, South Africa, $78,900
Julian Montoya, Argentina, $79,200
Second Row
Eben Etzebeth, South Africa, $68,700
Rob Simmons, Australia, $68,100
Back Row
Francois Louw, South Africa, $90,700
Jerome Kaino, New Zealand, $78,300
Duane Vermeulen, South Africa, $112,100
Halfback
Aaron Smith, New Zealand, $69,100
First Five
Nicolas Sanchez, Argentina, $218,600
Centre/Wings
Santiago Cordero, Argentina, $171,300
Ma'a Nonu, New Zealand, $136,700
Damian de Allende, South Africa, $116,000
Bryan Habana, South Africa, $128,900
Fullback
Ben Smith, New Zealand, $143,700
Listen to Radio Sport every week, the day before each fantasy round gets underway, to hear Dr Stats chat with D'Arcy Waldegrave about the latest fantasy news and advice.
On the bench:
James Slipper, Australia (benched)
Wyatt Crockett, New Zealand (out)
Fourie du Preez, South Africa (out)
Lood de Jager, South Africa (benched)
Joaquin Tuculet, Argentina (out)
Marcelo Bosch, Argentina (out)
Juan Martin Hernandez, Argentina (out)
Juan Imhoff, Argentina (out)
Leonardo Senatore, Argentina (out)
Pablo Matera, Argentina (out)
Agustin Creevy, Argentina (out)
Guido Petti, Argentina (benched)
Martin Landajo, Argentina (benched)