"That is an unbelievable shot, that is a terrific shot," former Australian batter Mark Waugh said on Fox Cricket.
"You just don't see that shot too often because that is so hard to play.
"To get that much power, that is a freakish shot. Unbelievable."
Former Australian wicketkeeper Brad Haddin continued: This is a bit of calypso cricket. He's opened the front side of his body and checked that ball over extra cover, into the second tier."
Australian cricket legend Adam Gilchrist tweeted: "I'm sure there has been a better shot in the history of the game, but I just can't remember it!"
Former Indian batter Gautam Gambhir posted: "You are not allowed to do this!"
Cricbuzz reporter Bharat Sundaresan tweeted: "The number of special moments that Kyle Mayers has already given us in only 18 months of being an international cricketer with this one on top of that list of course."
Footage of Mayers' shot registered more than 500,000 views on Twitter in less than three hours.
Mayers was later dismissed by Australian paceman Pat Cummins in the 10th over for 39 (36) as the West Indies registered a team total of 9/145.
Jamaican all-rounder Odean Smith contributed a crucial 27 (17) at the death, while paceman Josh Hazlewood was the pick of the Australian bowlers with three wickets.
Steve Smith was dropped for the series opener, with T20 globetrotter Tim David edging the former Australian captain out of the starting XI.
