England slipped to 68-2 at dinner on day four of the pink-ball Ashes test, with Nathan Lyon hurting the tourists' hopes of completing a record run-chase of 354 at Adelaide Oval.
Joe Root's side require a further 286 runs to level the five-test series but history suggests that won't happen.
Australia's 315-6 against England in 1902 remains the highest fourth-innings total in a successful test run-chase at Adelaide Oval, while England have never chased down more than 332 to win a test.
Yesterday's opening session ended with captain Steve Smith's side being rolled for 138 in their second innings, a by-product of Jimmy Anderson's maiden five-wicket haul in Australia.
Alastair Cook and Mark Stoneman started positively in response but Lyon snapped their 53-run opening stand, removing the former captain for 16 with the help of the Decision Review System (DRS).