Australia lost the toss but won the opening session of the first Test, reducing South Africa to 4-78 on Thursday at the WACA.
Skipper Faf du Plessis was 37 not out at the meal break on day one, having dug in with Temba Bavuma after a woeful opening hour from the tourists.
The Proteas were 4-32 when drinks were called following JP Duminy's dismissal, which came after opener Stephen Cook and talented first drop Hashim Amla were out edging for ducks. Not since England were 2-4 in 1998 has a side started a WACA Test so poorly.
Dean Elgar, who recorded a pair on Test debut at the ground in 2012, continued the slump in the eighth over when he was caught behind off the bowling of Josh Hazlewood.
It's been 10 years since South Africa had lost three or more wickets in the opening 10 overs of a Test.