It didn't appear there was any contact on the play. Rose was unable to return and was on crutches afterward.
With Rose back, the Bulls were expected to challenge LeBron James and the Miami Heat for supremacy in the Eastern Conference and contend for their first championship since the Michael Jordan-Scottie Pippen era. Instead, they're in a familiar spot trying to get by without their cornerstone player.
"We, of course, feel very badly for Derrick. He's in good spirits, about as well as can be expected under the circumstances, and he's already thinking about his rehab," coach Tom Thibodeau said Sunday, before the team announced their star was gone for the season. "Typical Derrick. He's concerned about his team, his teammates."
The top-seeded Bulls bowed out in the first round of the playoffs in 2012 against Philadelphia after Rose went down and fell into a season-long holding pattern without him last year, waiting for a return that didn't happen.
His recovery took on a circus-like feel. Fans saw him shooting and dunking before games last season and wondered why he wasn't playing, particularly as the Bulls fought through injuries and illnesses down the stretch. Adidas released videos documenting his progress, but Rose mostly stayed in the background, saying little about his recovery. That changed midway through the season.
There was also speculation that Rose's camp was advising him to sit out last season and that there was a rift with the organization, particularly after older brother Reggie Rose ripped management for standing pat at the trade deadline. But Derrick Rose denied that.
All of that faded into the background with Rose back this season and insisting he could regain his MVP form.
He was off to an up-and-down start. He was averaging 15.9 points and was shooting just over 35 percent.
He was looking a little better in his last two games, with 19 points in a loss at Denver and 20 against Portland.
Without Rose, veteran Kirk Hinrich figures to start with second-year pro Marquis Teague backing him up.
"I think we have an understanding of what we need to do," Thibodeau said. "We can't feel sorry for ourselves. We have to circle the wagons, and then get out there and get the job done."