John Lackey became the first pitcher to start and win a Series clincher for two different teams, allowing one run over 6 2-3 innings, 11 years after his Game 7 victory as an Angels rookie in 2002.
With fans roaring on every pitch and cameras flashing, Koji Uehara struck out Matt Carpenter for the final out. The Japanese pitcher jumped into the arms of catcher David Ross while Red Sox players rushed from the dugout and bullpen as the Boston theme Dirty Water played.
And the Red Sox didn't have to fly the trophy home. For the first time since Babe Ruth's team back in 1918, Boston won the title at Fenway Park. The 101-year-old ballpark, oldest in the majors, was packed with 38,447 singing, shouting fans anticipating a celebration 95 years in the making.
There wasn't the cowboy-up comeback charm of "The Idiots" from 2004, who swept St Louis to end an 86-year title drought. There wasn't that cool efficiency of the 2007 team that swept Colorado.
This time, they were Boston Strong playing for a city shaken by the marathon bombings in April.
After late-season slumps in 2010 and 2011, the embarrassing revelations of a chicken-and-beer clubhouse culture that contributed to the ouster of manager Terry Francona, and the daily tumult of Bobby Valentine's one-year flop, these Red Sox grew on fans.
Just like the long whiskers on the players' faces, starting with Jonny Gomes' scruffy spring training beard.
Across the northeast, from Connecticut's Housatonic River up to the Aroostook in Maine, Boston's eighth championship will be remembered for all the beard-yanking bonding.
Ortiz, the only player remaining from the 2004 champs, had a Ruthian World Series. He batted .688 (11 for 16) with two homers, six RBIs and eight walks including four in the finale for a .760 on-base percentage in 25 plate appearances.
"When we started rolling, nobody never stopped the train," Ortiz said.
Even slumping Stephen Drew delivered a big hit in Game 6, sending Wacha's first pitch of the fourth into the right-centre bullpen.
By the time the inning was over, RBI singles by Mike Napoli and Victorino had made it 6-0, and the Red Sox were on their way.
The win capped an emotional season for the Red Sox, one heavy with the memory of Patriots Day, when three people were killed and more than 260 hurt in bombing attacks at the Boston Marathon.
The Red Sox wore "Boston Strong" logos on their left sleeves and erected a large emblem on the Green Monster as a constant reminder.
A "B Strong" logo was mowed into centre-field grass at Fenway.
Among the players blamed for the indifferent culture at the end of the Francona years, Lackey took the mound two days shy of the second anniversary of his elbow surgery and got his first Series win since the 2002 clincher. He pitched shutout ball into the seventh, when Carlos Beltran's RBI single ended the Cardinals' slump with runners in scoring position at 0 for 14. Junichi Tazawa came in with the bases loaded and retired Allen Craig on an inning-ending grounder to first. Brandon Workman followed in the eighth and Uehara finished.
St Louis had been seeking its second title in three seasons, but the Cardinals sputtered. Symbolic of the team's struggles, reliever Trevor Rosenthal tripped while throwing a pitch to Ortiz in the eighth, balking Dustin Pedroia to second.
Pedroia had revived memories of Carlton Fisk's 1975 Game 6-winning home run, sending a first-inning drive about 3m foul of the Green Monster foul pole and waving his left arm once to try to urge the ball fair as he came out of the batter's box.
Lackey escaped a two-on, none-out jam in the second when he retired Matt Adams and David Freese on flyouts and, after a wild pitch, struck out Jon Jay. Boston wasted a similar threat in the bottom half, then went ahead on the third.
Jacoby Ellsbury singled leading off and went to second on Pedroia's grounder. Ortiz was intentionally walked, Napoli struck out and Gomes was hit above the left elbow with a pitch, loading the bases.
Victorino, wearing red, white and blue spikes with an American flag motif, had been 0 for 10 in the Series and missed the previous two games with a bad back.
Dropped from second to sixth in the batting order, he took two balls and a called strike, then turned on a 150km/h fastball and sent it high off the Green Monster, the 11m-high wall in left. Gomes slid home as Yadier Molina took Matt Holliday's one-hop throw and applied the tag, then argued with plate umpire Jim Joyce.
Victorino, pumped with emotion, went to third on the throw and pounded his chest with both fists three times.
- AP