Smith, though, will start favourite and with a half-marathon personal best almost two minutes quicker than Kiros, the American-based Kiwi is understandably optimistic.
"The series is a new concept and I am definitely more confident running a half-marathon [than the shorter distances of 5km and 10km]," says Smith, who is preparing to compete in the New York Marathon on November 4.
"My coach [Ray Tracey] never really likes me to run a half-marathon so close to a marathon and maybe I wouldn't have had I not been in contention [for first prize], but I think he understands my reasons for running.
"It will be pretty cool to win the money. It will be the most money I have won running."
Smith, based in Providence, Rhode Island, has not had time to wallow in the disappointment of her Olympic performance - marrying long-time boyfriend and fellow runner Pat Tarpy earlier this month .
The pair tied the knot in Tarpy's home town of North Yarmouth, Maine, but such is her focus on training for New York, Smith went for an hour-long run on the morning of her big day with her two bridesmaids; Molly Huddle, the US international, and Irish athlete Mary Cullen.
In the Big Apple this month, Smith, who finished fifth in the 2010 and 2011 New York Marathons, is seeking a top three finish but explains next season could see her shift priorities to the track for the world championships in Moscow.
"I watched the track events in London and a lot of people who were running track had moved up to the marathon," Smith, 30, explains.
"Not as many people are now running track, which is a little weaker. I definitely think I could have done better on the track [than the marathon at the Olympics].
"I did say in the past that I would never run track again but my coach and I have talked about me doing more 5km and 10km and that could be also what I do in Moscow."
Yet switching back to the Boston Half-Marathon - should she complete victory in the BAA Medley Series, what would she spend the money on?
"The honeymoon, and we'd be looking at somewhere like the Caribbean," she says. "We haven't planned one yet but we hope to go away after New York."