"MRR (Measles) vaccine gives black boys autism at a rate 240 per cent greater than their white counterparts," one of the hosts said.
"It's wiping black boys out, not just with autism — so what the pharmaceutical industry is doing is getting a customer for life."
Mundine's comments were immediately labelled as "dangerous" by others, especially in the wake of a measles outbreak in Australia — he was also heavily ridiculed for the tweet with many punters suggesting he had taken one punch too many.
Mundine's comments come on a day where a university student who travelled around a host of places in Sydney became the 35th person to be diagnosed with measles since Christmas.
New South Wales Health is now warning students, train passengers and shoppers in Sydney and Maitland to watch out for symptoms of the highly contagious disease.
NSW Health's communicable diseases director Vicky Sheppeard said people should be alert for symptoms up to at least April 23 and stressed the importance of being vaccinated.
"We cannot stress enough the need for holiday-makers to be vaccinated before travelling to South-East Asia because the majority of cases we are seeing are being brought home," Dr Sheppeard said.
"NSW already has record immunisation rates but the community is not fully covered and measles is highly contagious and can stay in the air for up to 30 minutes after an infected person has left a room.
"If you're not sure if you have had two doses of measles vaccine which provides lifelong protection in 99 out of 100 people, it is safe to get another jab, particularly if you're heading overseas."
Mundine, a former rugby league star before his boxing career took off is not the only person to have caused controversy as an anti-vaxxer, with the wife of Gold Coast Titans star Bryce Cartwright revealing they did not vaccinate their kids.
Mundine currently has no upcoming fights on the agenda but was floored in 90 seconds, when last in the ring by Jeff Horn, in November.
