"This is a tragedy for the families involved and our thoughts are with them at this time," Horne said.
"Serious crashes are also heart-breaking for police staff and those from other emergency services.
"This incident highlights the risk of driving at speed and the tragic consequences that can result when a driver refuses to stop and instead chooses to evade the police."
An investigation into the crash is ongoing.
The matter has also been referred to the Independent Police Conduct Authority.