A 22-year-old male was also taken to hospital by road with moderate injuries.
The Serious Crash Unit was investigating last night and the road was closed for several hours.
The crash took place on a stretch of road previously known as the "highway of death" because of the high number of fatal crashes. Between 2003 and September 2010 the road claimed 31 lives and 56 people were seriously injured.
Another crash occurred early yesterday morning about 1km further along SH2, just before Ngatea, which was also swathed in fog.
The smashed up car, which had wiped out a power pole, was still in the paddock several hours later.