Fire and Emergency were called to a blaze at Victoria University's Rutherford House this morning.
Four crews found a small fire in the building's upper levels about 5.30am. It has now been put out and there are no reports of any injuries.
A Victoria University spokesperson said the building's sprinkler system were activated, which caused some water and smoke damage.
Levels 3-12 of the building are closed while the damage is assessed.
Staff who usually work in Rutherford House have been asked to work from home or another location today.