Emergency services are responding to a two-vehicle crash near Waimate.
Police say they were called to the crash on the Waimate Highway (SH1) at 1.27pm.
A St John spokesperson said they sent four ambulances and one manager to the scene.
It treated one patient in a serious condition and two in a moderate condition. All patients were transported to Timaru Hospital, they said.
Fire and Emergency NZ spokesperson said two fire trucks from Glenavy and two trucks from Waimate were attending the incident.