Two people are in a serious condition after a major crash near Mosgiel.
The accident occurred on State Highway 87, near Tirohanga Road in Otago just after 5pm.
A police spokesman said three of the five men in the Subaru Impreza were thrown from the vehicle when it crossed the centre line and rolled.
It is understood others were trapped in wreckage for some time.
The men - all from Otago - were aged between 22 and 34, the spokesman said.