Chief operations officer of KiwiRail, Todd Moyle, said a freight train, which had been heading to Palmerston North from Napier, collided with the car.
It is understood the train and car came to a rest about 100 meters past the Troup Rd crossing. Emergency service personnel are working at the front of the train, Stuff reported.
"Sadly, it has been reported there are two fatalities, and our thoughts are with their families and loved ones," Moyle said.
The Serious Crash Unit is investigating and the road may be closed for some time.