It followed another crash in Manurewa early this evening when police attempted to stop a stolen vehicle about 4.45pm.
The vehicle fled from police and a short time later collided with another vehicle on Russell Rd.
A police spokesperson said the police pursuit started around Magic Way on Alfriston Rd and the intersection Great South Rd, and lasted less than three minutes.
A female passenger in the fleeing vehicle suffered serious injuries and a male driver from the other victims vehicle had moderate to serious injuries.
Both have been transported to Middlemore Hospital.
The driver of the stolen vehicle fled from police on foot and is still at large.
Russell Rd remains closed, diversions are in place and people are asked to avoid the area while police investigate the scene.
Cordons are visible on the street, which is marked out with orange cones. Several police vehicles and an ambulance were at the scene.
"Fleeing driver incidents can have serious consequences and this incident clearly demonstrates what can happen if a driver chooses not to stop for police," a police spokesperson said.
The incidents are among a spate of crashes across the country, including one fatal, which have made for a tragic start to Labour Weekend.