No cure has yet been found and the trek helps fund research into finding one.
Joint organiser Barry Scott, of Dannevirke, was in Masterton yesterday drumming up support for the trek and distributing flyers. He said volunteers from all walks of life take part in the trek, including professionals.
"One woman comes out from Australia every year to take part and four women arrive from Invercargill," he said.
The route of the trek will be marked with pink ribbons as it heads through Wairarapa, allowing trekkers to move at their own pace with the support of marshals on horseback and quad bikes.
The marshals will include medics, vets and farriers and a caterer from Waitomo follows the trek each day providing on-the-spot meals.
After leaving Alfredton on February 23, the trek travels through Bideford, Wainuioru, Gladstone, Martinborough and Dyerville before finishing at Lake Ferry.