There are almost twice as many games in the Major League Baseball regular season as any other major sport.
This makes it the perfect sport for system betting if you find a winning angle and stick to it, you should come out on top over the long run. The number of games increases the likelihood of regression to the mean.
Look for division underdogs:
Division rivals play each other 18 times every season in the MLB. The familiarity that this fosters has led to a much more level playing field in games between division rivals as opposed to out of division matchups. Underdogs in division matchups have won 43.6% of games since 2005 and produce a return on investment 4% higher than non-division underdogs.
A high expected run total is also a good indicator as to when you want to be backing a division underdog as their win rate closely correlates with the run total for that game. Division underdogs in games with a total of 10.5 or higher have produced a ROI of nearly 8% since 2005.