The main highway between Blenheim and Nelson will be closed for seven weeks as the road is repaired after heavy rain and flooding in August.
Waka Kotahi NZTA said State Highway 6 from Hira and Ronga Rd near Rai Valley will close between November 1 to December 18.
"To keep everyone safe and finish the work as quickly as possible, we must close the road for seven weeks. We realise this is a substantial amount of time, but the route is currently vulnerable," Waka Kotahi's top of the south system manager Andrew James said.
"Another serious weather event could seriously damage it and see it closed for months. We must get this work done as quickly as possible."
The road was impacted by landslips after heavy rain caused flooding and prompted a state of emergency in August. The highway was initially closed, but Waka Kotahi opened the road to allow people between the two towns while another state highway was closed for storm-related repairs.