State Highway 1 was reopened near Hampton Downs following a four-car crash that resulted in both lanes being temporarily closed.
Police were notified of the incident around 3.45pm and initial reports suggest four people have been injured.
The Trustpower TECT Rescue Helicopter attended the scene and said several occupants of the vehicles sustained minor injuries.
One woman was seriously injured and was stabalised at the scene before being airlifted to Waikato Hospital for further treatment.
Both directions were blocked until 6pm but the New Zealand Transport Agency said the southbound lane had reopened about 6pm.