SPCA head and staunch animal welfare advocate Bob Kerridge admits that some animal testing will be required as part of a new regime which is designed to prove the safety of party pills and synthetic cannabis.
MPs on a Health Select Committee unanimously agreed that the Psychoactive Substances Bill should be passed into law with amendments which included tentative limits on animal testing.
A new expert panel designed to approve legal highs for sale would also have to ensure that any clinical or preclinical drug trials did not rely on animal testing "if suitable alternatives existed".
Mr Kerridge, a member on the expert panel, said: "The eventual conclusion is that it might be necessary to have some animal testing, but we would hope to limit that as much as possible."
He said it was difficult to admit that some animals would be used in drug trials, and he felt some reluctance on the panel to allow experiments on rats or dogs for the purpose of approving recreational drugs.