Waikato University international law expert Alexander Gillespie said the significance of the missile attacks could not be understated.
"It's huge. It's absolutely monstrous. To actually get directly involved, targeting [Syrian President] Assad - as opposed to targeting Isis - is a game-changer."
Gillespie said all eyes would now be on Syria and Russia's response.
"There are American troops in Raqqa right now, fighting the Islamic State. The question is whether Assad will attack the American troops
"And the second question is how will the Russians respond? Because the Russians have the capability to strike back.