"We've been here since March last year and in that time three people have died."
Traffic was down to one lane on the road, motorists are asked to avoid the area and to expect delays.
"We thank motorists in advance for their patience."
It is the second serious crash on Russley Rd in just over a month.
29-year-old Benjamin Simon Furze died in a crash on December 30.
Police were called to the serious single-vehicle crash in Harewood at about 10.45pm.
Passers by had stopped to help before emergency services arrived and spoke about the carnage on social media.
Two other people sustained serious injuries in the crash, which is under investigation.
In June last year, two people were killed in a crash on the road.
A young man was reported to have driven the wrong way before smashing head-on into another vehicle, killing himself and the other driver.
