The highway, at the intersection with Hannah Rd, was closed for several hours after the crash but police and the NZ Transport Agency confirmed about 3.50pm that it had reopened.
The Serious Crash Unit was investigating.
A Hato Hone St John spokesman earlier said four people were taken to hospital by ambulance.
Three were in critical condition and one in serious condition.
The road was blocked at the intersections of SH30, Lee Rd and Robinson Ave, causing traffic to build up as heavy vehicles such as logging trucks needed to be diverted back towards Ngongotahā.
A Rotorua Daily Post reporter at the scene earlier said police, Fire and Emergency (Fenz) vehicles and four St John ambulances were present.
Three of the ambulances were seen departing the site of the crash with their lights activated.
A Fenz spokesman said crews were called to the two-vehicle crash about 11.18am and people were trapped in each vehicle.
“Crews are working with extraction gear,” he said this morning.
Three fire trucks and two support vehicles were at the scene.