Placemakers stores around the country have joined six South Island Mitre 10 outlets in banning the sale of butane-based products to anyone aged under 18.
Chief Coroner Judge Neil MacLean revealed last week that 63 people had died in butane-sniffing incidents since 2000, and Associate Minister of Health Peter Dunne asked those selling the potentially fatal substance to take more responsibility.
Placemakers' chief executive John Beveridge said the decision to ban the sale of butane-based solvents to under 18-year-olds across all of its stores was "being a responsible corporate citizen".
"We don't want to be part of the problem".
Mr Beveridge called on smaller retailers to follow Placemakers' lead, saying it was difficult for the Government to act on butane-based products.