A person is in critical condition this morning after a crash near the Matamata turnoff on State Highway 5.
A police media spokeswoman confirmed the road had reopened at 2.35pm.
She said the Serious Crash Unit attended the scene and inquiries were ongoing.
A St John spokeswoman said a helicopter had initially been called but was stood down.
She said one patient in a critical condition and two in a moderate condition were being transported by road to Waikato Hospital.