Police inquiries into the crash which killed one person on State Highway 3, north of Whanganui, on Sunday are ongoing.
Emergency services were alerted to the crash at the intersection of SH3 and Watt Livingstone Rd at 12.30pm.
Diversions were in place for more than four hours and before the road re-opened at about 5.30pm.
A police spokesperson said the crash involved a motorcycle and a car.
Waka Kotahi NZ Transport Agency said SH3 was closed between Rapanui Rd and Kai Iwi Valley Rd.
"Please avoid the area or follow the directions of emergency services on site to detour."
The Serious Crash Unit was in attendance.