One person is in a critical condition and another is trapped after two trucks and a car collided on State Highway 1 north of Wellsford.
One person with critical injuries has been taken to hospital by helicopter after being freed by fire crews from a vehicle.
A second person was still trapped in a truck shortly after noon and two more people had serious injuries, a police spokeswoman said.
Fire crews were working to free the second person.
Two vehicles had rolled in the crash but it was not initially clear whether they were the trucks or not.