Five men and one woman have been arrested and charged with numerous offences, including possession of firearms, possession of cannabis for supply and participation in an organised criminal group.
Police said further arrests and charges are likely.
Detective Inspector Mike Foster said the search warrants were the result of 12 months of an ongoing operation by the Hawke's Bay Organised Crime Unit into the sale of illegal drugs throughout the region.
"Organised crime is all about money," he said. "Attacking the profits of organised criminal groups is a key part of our strategy to deter and disrupt their operations, and combat the illegal activities they're involved in."