The branch clinics in Featherston and Martinborough would remain open, with the Carterton site becoming a "hub" for the business.
The company still plans to open a branch in Masterton in May on the site of the former Dave Anderson motorcycle business in Queen St.
John Cameron, of Carrington House, said he was concerned about the increase in traffic so close to the corner and Andersons Line.
"I've had a number of calls from other people now that can't believe that Land Transport would even consider such an activity on such a difficult piece of highway."
"The site is on a very busy part of the highway with a lot of traffic and the Taratahi corner is a very sharp corner ... we are talking about traffic movement in and out of up to 150 vehicles a day."
Mr Cameron said it was a dangerous area, with long stopping distances for heavy vehicles and a number of accidents occurring on that stretch of road.
"Over the years we've had a number of vehicles through the fence ... sometimes just getting in and out of our gate is a real mission."
"We think there are better sites available ... it seems a pity to jeopardise safety by choosing this site when within less than a kilometre there are other sites that may be more suitable."
The fact that the proposed development was a commercial activity located near the remnants of Carterton's heritage area was another reason for concern, Mr Cameron said.
SH2 residents Avril and Peter Baker were also opposed to the subdivision.
Mrs Baker said most of the neighbours she had spoken to so far were also against the proposal. "The general feeling is that there are better sites for the vets to use," she said.
The Bakers' submission states that it is "already a busy and dangerous road".
"The amount of traffic turning in to and out of the veterinary practice can only increase the chances of a serious accident.
"We fail to understand why a traffic flow report was completed during what must be the quietest time of day - noon to 2pm."
Their submission also expresses concern over the heritage value of the area.
Submissions from other residents highlighted concerns with traffic safety, as well as a change in designation from rural residential to commercial.
The application states the company has been looking for a new site since 2012.
Several sites, including one in Waingawa, were initially investigated although a site with street frontage in Carterton was the preferred option.
Director Adrian Evans said the company was aware there were concerns and was willing to work with residents. "We are conscious of people's concerns - that's understandable, and we are willing to make any adjustments that are necessary."
It would be better to shift traffic from the centre of town to the proposed site, he said.
"We've conducted a traffic survey and there is already an existing driveway there that's used.
"We are moving traffic from one part within the congested part of Carterton to another."
The clinic's current location was becoming "impossible".
"We are trying to do our best for our business and our community as well. We want to help and grow Carterton and that's part of who we are and what we want."
There were already several commercial buildings in the area, including the Taratahi Hotel, Mr Evans said.
"We are not knocking down anything, we are not destroying cottages. This is bare land."
It had been difficult finding a suitable site, with the company eventually resorting to "door-knocking" to find the property at SH2.
If the plan goes ahead the company plans to sell the premises on High St South.
Submissions on the application close April 1.
