Bethune and crew members from his non-profit organisation, Earthrace, was at the Piedras Blancas National Park, in the Punta Encanto section, when the incident happened.
He had just walked past a pile of leaves when he felt a sudden jab to the back of his left leg - and knew straight away he had been bitten by a snake.
He and the crew were forced to trek about 2.5km down rough jungle terrain and waterfalls to get to a boat that took them to the mainland for urgent medical treatment.
Within hours, his venom-infected leg had doubled in size and become so swollen, doctors were getting ready to operate if the venom had spread further up past his groin.
He said his condition remained mostly the same throughout the night - until things started to improve this morning.
"The operation to reduce swelling (is) less likely to happen now," he said.
Bethune said he had also spoken to his adult daughters.
"My girls (were) really upset, as you'd expect."
He thanked members of the public, in New Zealand and around the world, who had sent him messages of love and support over the last few days.
"I'm super grateful for all their support back home. At times, this is a lonely gig.
"Something like this happens and I realise how much people care about me and my team's work. A very humbling experience."