State Highway 1 south of Blenheim will close for five nights to allow for work to repair the road surface in the Weld Pass.
The road will close between 7pm and 6am from next Sunday until Thursday 9 December.
Waka Kotahi journey manager Tresca Forrester said drivers will be allowed through every two hours overnight and emergency vehicles will be accommodated at all times.
"Waka Kotahi thanks all drivers who may be inconvenienced and encourage everyone to plan for the opening times if they can. Traffic will be queued at each end between opening times."