One person is seriously injured following a crash on State Highway 2, near Waipawa.
A police spokesperson said the crash involved a car and a truck, and occurred about 7.40am just south of the Waipawa Bridge.
A helicopter has been directed to the scene and motorists have been asked to avoid the area. The road was expected to re-open by 11.45am.
It is the second crash in the area in 48 hours, after a car and truck collided between Waipawa and Hastings on Saturday.
A spokesperson for Hawke's Bay hospital confirmed two people had be transferred to hospital, both women in their 20's.
One was in a critical condition, and the other was stable.
Meanwhile, three people including a baby have been injured in a crash involving a truck and a car in south Taranaki.
A Fire and Emergency spokesman said they received a call about the collision at the intersection of Eltham and Aurora Rds in Awatuna, about 8.18am.
One person with moderate injuries was trapped in a vehicle and firefighters were extricating them.
Two other people including a baby had minor injuries and were out of the vehicle.
Emergency services were clearing a landing pad for a helicopter.
The 19-year-old disappeared without her wallet or mobile phone.