A section of the ceiling at The Base collapsed today after heavy rain.
Part of the ceiling at Fish Punk in the food court collapsed just before 10.30am.
No one was injured.
The Base centre manager Simon Betts said torrential rain in Hamilton had caused a major leak.
Bits of the ceiling could be seen on the floor and work was underway to repair it.
An update on The Base's Facebook page said it was taking a cautious approach to inspecting all surrounding areas of the ceiling and some stores may be closed temporarily while a team of builders inspected.
"The safety of our customers and staff working in the centre is our top priority so please bear with us and be patient while these checks are carried out," the post said.
At midday the area at the rear of the food court near McDonald's was cordoned off, but the food court remained open. Fish Punk was closed.
At lunchtime most of the tables in the food court were full with diners.
Emergency services were called to the scene in Courtenay Place about 8.25pm.