Four people were taken to Taumarunui Hospital following a two-car crash on State Highway 4 in the Ruapehu District.
Police said they were notified of the crash near the Makatote Viaduct around 2.30pm on Sunday.
Hato Hone St John said they sent two ambulances to the scene of the crash.
Four people were taken to Taumarunui Hospital, two in a serious condition and two in a moderate condition.
A Fire and Emergency New Zealand spokesperson said they were called to the scene to assist St John and police.