One person is understood to be seriously injured following a crash in Drury.
Police were called about 10.35am to the corner of Pitt Rd and Great South Rd, near Drury, following a serious two-vehicle crash.
"Initial indications are that one person has been seriously injured," police said in a statement.
The road will be closed with diversions in place while the Serious Crash Unit attends the scene.
Police are advising motorists to avoid the area if possible.