The 15-minute operation involved about 25 members of the emergency services, including the Arrowtown, Frankton and Queenstown brigades, along with police and St John.
Both vehicles sustained significant damage. They spun together in the crash and ended up wedged against the winery's stone wall.
All four people involved were believed to be tourists.
On Tuesday, six cars were involved in a shunt accident about half a kilometre down the road near the AJ Hackett Bungy Centre bridge over the Kawarau River. No one was injured.
Mr Clark said: "There's been a few [accidents] in recent years and a couple in the past month - just people not paying attention on the roads."