A poisons expert says people are frequently exposed to carbon monoxide but the public can be assured the George family tragedy was a highly unusual accident.
Ashburton woman Cindy George died alongside her three children, 5-year-old Pio Scarlet Jetejura Raukete, 3-year-old Teuruaa Junior George, and 2-year-old Telyzshaun Gordon Ricardo Nelder Kruz George.
Their bodies were found on Thursday and a car was believed to have been left running in an internal garage.
National Poisons Centre Toxicologist Dr Leo Schep said carbon monoxide could be an "insidious" killer, leaving its victims little or no time to act.
Apart from symptoms of drowsiness or headaches, people may not know they were being poisoned.