One person died in a mid-morning crash between two trucks on the busy State Highway 65 near Springs Junction.
A second person, aged in his 20s, was flown by the NZCC West Coast Rescue Helicopter to Grey Base Hospital with moderate injuries.
The crash occurred about 9km north of Springs Junction township, on the Shenandoah highway, where truck numbers have skyrocketed since it became the main highway between Christchurch and the Picton ferries with the closure of the coastal route after the Kaikoura earthquake.
Diversions were in place after the crash, and the New Zealand Transport Agency advised motorists to take the alternative route through Reefton.
The crash closed the highway about 500m south of the intersection with West Bank Rd.