If Bisphenol-A was a purely scientific issue, working through it would be easy. But use of the chemical has become a political football with industry players who produce three million tons of it globally each year or add it to the packaging containing their food products squaring off against campaigners convinced it is toxic to humans and politicians who have joined their cause. The image below, which Professor Robertson showed yesterday, suggests the industries dependent on BPA (alternatives deemed to be less problematic are more expensive) have in the US lobbied government agencies and underwritten scientific research as part of a campaign to fight a Bisphenol-A ban.
What do the scientists think?
Clearly, opinions vary among scientists on the safety of Bisphenol-A and a fairly extensive body of research has failed to conclusively point to a risk great enough to have regulators universally moving to ban BPA.
One view of Bisphenol-A is presented by Professor Richard Sharpe of Medical Research Council Human Reproductive Sciences Unit based at University of Edinburgh. In December, as Breast Cancer UK mounted a campaign to have BPA banned in Britain, he told my colleagues at the Science Media Centre in London:
"There is no direct evidence that links bisphenol A exposure in women, or in animal studies, to the development of breast cancer. Bisphenol A is an extremely weak oestrogen and is therefore unlikely to contribute significantly to a woman's lifetime oestrogen exposure (and thus to her risk of breast cancer). Much of the data on low dose effects of bisphenol A have proved to be unrepeatable in more detailed, follow-up studies that have used the route of exposure (oral) relevant to humans, meaning that they do not satisfy one of the fundamental criteria for good science. In my opinion, any call for action on bisphenol A first requires direct evidence that, at human oral exposure levels, it can be shown capable of inducing breast cancer in animal models."
Locally, Ian Shaw, Professor of Toxicology at the University of Canterbury, says there are grounds for limitations on the use of BPA. He told the Science Media Centre:
"I don't think we should ban BPA, but I think we should control its use much more carefully. BPA is the chemical used to manufacture polycarbonate plastics, is a component of lacquers used to line food cans, and is used in some dental fillings - the problem is that it mimics the female hormone. Small doses over a long time can initiate female hormone responses.
"In males this might result in undescended testes or other sex organ deformities, but in females it is possible that some breast cancers might be stimulated. A specific type of breast cancer (estrogen receptor positive breast cancer) grows when the female hormone, estrogen, binds to a specific receptor in the cell; when the receptor is occupied the cancer cell divides and the cancer grows. An estrogen mimic such as BPA can bind to the receptor and stimulate the breast cancer cell to divide. Controlling its use while allowing it to be used for the benefit of society (e.g. in some medical devices) will reduce exposure and so reduce the risk."
University of Missouri-Columbia researcher Fredrick vom Saal is at the other end of the spectrum. He said recently:
"Among people who have actually read the literature, there is no debate, just an illusion of controversy. This is a phenomenally potent chemical."
New Zealand situation
BPA is definitely on the radar of the New Zealand Food Safety Authority, hence the prominent discussion of it at the food safety conference. But so far the regulator has held firm on its advice that there is no cause for concern:
NZFSA's view, based on current scientific evidence, is that there is no health concern associated with BPA, a chemical found in plastics, including food packaging and babies' bottles. We are maintaining a very close watch on developments in case new data comes forward that changes this view.
Products containing BPA are pervasive in the market here, though non-BPA containers are also on sale, particular when it comes to baby bottles and sippy cups. The media has taken an interest in the issue, with varying results.
BPA - tip of the iceberg?
As the New York Times piece points out, Bisphenol-A isn't the only endocrine-disrupting chemical being used in food packaging.
Patricia Hunt, a biologist at Washington State University, in Pullman [said]: "It's just the one that's captured the attention, because researchers like me have gotten into the field and gone, 'Holy cats! We're all exposed to this.' There's been a heavy industry response, and we've gathered our forces together a little more strongly to shine a light on it. This is the poster child for this group of chemicals. Academic scientists are saying we need to do something, and we need to do it fast."
Professor Robertson helpfully cycled through the other chemicals used in food packaging that may be interacting with food with largely unknown consequences.
There's diisopropylnaphthalenes (DIPNs), chemicals from recycled paper, used for board in food packaging, may migrate into food. Then there's the packaging chemical ITX, which isn't on food regulators' risk lists but is raising concerns nonetheless. There's also concern that inks used in food packaging labels may leach into food, in some cases being absorbed through plastic containers, with potentially negative consequences.
Professor Robertson's presentation was fairly open-ended - the lack of scientific knowledge about these chemicals from the likes of Nestle and Tetra-Pak, major users of food packaging, concerns him. But like the scientists attempting to examine the concerns of BPA's vocal critics, he isn't able to make a call one way or other as to the safety of BPA.
"They do have a point, but the effect in humans is still questionable," he said today.
One worrying issue he raises, is that traceability in the food industry - the ability to track where products and their packaging have come from, is getting more difficult to follow when technology should be making it easier. He puts that down to the increasingly global sourcing of food packaging materials. Country of origin labelling for food is patchy, let alone the packaging the food comes in. A lack of robustness in packaging compliance warranty schemes around the world doesn't help.
Robertson, who consults to food manufacturers, had firsthand knowledge of the difficulties of tracing food packaging materials when he was asked to trace a company's food packaging through the company's entire supply chain.
"After three months, I gave up in defeat," he said.
Partisan politics on BPA
In the US, where a third of BPA is produced, the debate around its safety has become highly politicised with Democrats and environmentalists vocal in their concerns about it, while industry and Republican supporters claim there is no problem with it. Last week California rejected a BPA ban.
This month the European Food Safety Authority is expected to issue a long overdue update on BPA. The US Food and Drug Administration has also been reviewing its stance on BPA. The decisions these regulators make about BPA may determine its future use globally. Political pressure is no doubt encouraging regulators to make BPA a priority.
The new BPA studies underway are still a couple of years away from reporting. As the NYT explains:
The new, government-financed studies will try to determine whether BPA can play a role in obesity, diabetes, breast and prostate cancer and disorders of the developing immune, cardiovascular and nervous systems. Dr. Birnbaum said researchers would be looking for effects on learning and behavior, and also trying to find out whether there are "multigenerational" effects, meaning that exposure in a pregnant animal can affect her offspring and the next generations as well.
In the meantime BPA is, in most countries, considered safe and remains an integral ingredient in food packaging most of us come into contact with. But with a host of chemicals added to food packaging and growing mistrust among consumers when it comes to food safety, the industry, science and regulators have their work cut out for them reducing uncertainty around BPA's safety.
Peter Griffin is the manager of the Science Media Centre and the editor of Sciblogs.co.nz, where you can find more of his work and that of 35 scientists and science writers.
