Two people were taken to Whanganui Hospital in a serious condition following a single-car crash on State Highway 3 near Kaitoke.
Hato Hone St John said it was notified of the incident at 12.28pm on Thursday.
Powerlines were brought down on the vehicle, which resulted in it catching fire.
Two ambulances and one manager responded. Staff assessed and treated two patients before transporting them to Whanganui Hospital in a serious condition.
Two fire trucks and one support vehicle from Whanganui Fire Station responded. A Fire and Emergency New Zealand spokesperson could not say whether the people were in the vehicle when it caught fire.