Dyhrberg urged the jury to find that her client, who was drunk at the party, showed no murderous intent and was therefore guilty of manslaughter not murder.
Browne's defence during the trial has been based on the claim that she acted unconsciously, was suffering from an "automatism", and was badly affected by a plethora of alcohol and drugs.
She also claims to have had her drink spiked, noting that it "tasted funny".
"No premeditation, no planning, but in the midst of a party, music, friends, good times," Dyhrberg said.
She said the case was "all about Anna Browne's state of mind" and that witness testimony of her client's bewilderment, confusion and crying after the stabbing showed her lack of murderous intent.
A "delayed" urine test by police, some eight and a half hours after the stabbing, and the lack of a blood test meant it may never be known what Browne was thinking, Dyhrberg said.
"Without timely blood and alcohol tests we cannot go back in time and find out what was going on in her head."
She said another key piece of evidence was Browne returning to the scene, just moments after Stewart lay dying in the lounge.
"You do not go back to be at the mercy of the friends of the person you have just murdered," Dyhrberg said.
"You don't murder someone in front of witnesses. You don't return to the scene after being forcefully ordered to leave."
Earlier, Crown prosecutor Nick Webby said in his closing that Browne became increasingly agitated during the party.
He said Browne abused other guests and got into numerous scuffles before Stewart came to restrain her.
Witnesses described how Stewart dominated, intimidated and made Browne scared, telling her, "you f*** disrespectful b***, my nieces are f*** here".
He said Browne's disproportionate response was to grab a knife and stab Stewart.
This made her guilty of murder under both its legal definitions, he said, adding that she not only intended to kill when she plunged the knife 11cm into Stewart's face, but she was reckless to the dangers of her actions.
Webby described how, out of all the utensils in the kitchen, Browne chose the largest knife before approaching Stewart with it behind her back to maintain the element of surprise and then striking at her head - a vulnerable target.
"Can you really infer any other intention but an intention to kill?"
Webby said medical experts had testified during the trial that Browne suffered anti-social and attention deficit disorders.
He said the defence team's own medical expert had said during the trial that the attention deficit disorder combined with alcohol consumption had a direct relationship to Browne's violence and emotional responses.
These responses were "often out of all proportion to the triggering event", he said.
Justice Edwin Wylie will give his closing remarks tomorrow before the jury retires to deliberate.