Labour's Port Hills MP, Ruth Dyson, will retire at next year's election.
By then she will have been in Parliament for 27 years.
"This has not been an easy decision to make but it is one that has been made considerably easier by the fact that I am leaving at a time when Labour is strong and united, with a clear plan to deliver the policies that I have worked hard to develop," she said.
"I don't recall a time when Labour has been more united as a team or when we have had such an amazing recruitment of new activists."
Dyson is aged 61 and was first elected in 1993.