The death brings the Easter weekend road toll to two, which was the total amount of road deaths for the holiday last year.
Police were called to the crash, between Waipakihi Rd and Rangipo Intake Rd, at 3.27pm.
A central fire communications spokeswoman said three people were trapped, and they are assisting with extrication.
SH1 DESERT ROAD CLOSED - SERIOUS CRASH - 3:50PM
Due to a serious crash involving a tanker, the Desert Road is CLOSED from Waiouru to Rangipo. Please follow the directions of emergency services on site and expect delays. ^EL pic.twitter.com/ezhmMUZdVz
— Waka Kotahi NZTA Central North Island (@WakaKotahiCNI) March 30, 2018
Police have advised Desert Rd (SH1) is now closed due to the crash. They are advising motorists to use SH46 and SH49 as alternative routes.
"There are a number of injuries and a helicopter landing site has been set up to take patients to hospital."
NZTA has warned motorists to allow at least 90 minutes for the detour.
"The road is expected to be closed for some time so people should avoid the area if they can or check before they travel."
The Serious Crash Unit and the Commercial Vehicle Safety Team have been advised.
Earlier today one person died after a crash in Waikato. Emergency services were called to the crash, between Pokuru and Tirohanga Rds, Tirohanga in Kinleith between Rotorua and Taupo, at 10.52am.
Three young children were also injured and a woman left fighting for her life after a major crash between a car and a truck south of Matamata.
Two adults and the three children, aged eight months old, and 2 and 3 years old, were in a car that collided with a truck carrying frozen goods at the intersection of State Highways 27 and 29, in Waikato, at 9.45am.
Firefighters had to cut two people free from the wreckage. The 27-year-old driver of the vehicle was stabilised by paramedics at the scene before being flown to Waikato Hospital in a critical condition.