A photographer at the scene said Fenton St was cordoned off and a car was inside Urbano Bistro.
Another crashed car was on the right-hand side of Fenton St heading into town and there were tracks on the median strip.
A St John ambulance spokesman said four people were injured. One person had serious injuries and the others moderate injuries.
All were taken to Rotorua Hospital.
St John sent two ambulances, a first response unit and a rapid response unit to the scene.
A Fire and Emergency Northern Communications Centre shift manager said two people were trapped.
She said three fire trucks were on the scene assisting police and ambulance.
The Rotorua Daily Post approached Urbano Bistro for comment. The established restaurant is on Rotorua’s famed Motel Mile.
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