The couple will then fly to Dunedin, to take in Otago's history and natural attractions.
After touching down, Charles and Camilla will board the Taieri Gorge train at Mosgiel, taking a half-hour rail trip and arriving at the southern city's famous railway station a half-hour later.
From Dunedin Railway Station, the couple were expected to and walk to Toitu Otago Settlers Museum at 1.45pm.
Event organisers said the museum walk - the couple's first public walkabout of this tour - should be the best chance for members of the public to see the Prince and Duchess in Dunedin.
At Toitu, Charles and Camilla planned to meet descendants of Otago's earliest settlers in the museum's Smith Gallery.
Later, the Prince and his wife will again separate.
Prince Charles will visit Animation Research Limited in Dowling St, where he'll learn about the Otago city's achievements in innovation and entrepreneurship.
Meanwhile, Camilla had a literature event at the the University of Otago.
The event, kicking off just before 3pm, was planned as a way to showcase Dunedin's status as a Unesco City of Literature.
At 4pm, the royal couple will hook up again to visit Orokonui Eco-sanctuary, northeast of the city.
The eco-sanctuary, also known as Te Korowai o Mihiwaka, is home to animals including the critically-endangered Haast Tokoeka kiwi, the South Island robin, tieke or South Island saddleback, and kaka.
It's also home to the jewelled gecko, and to tuatara and kaka.
Prince Charles, known for his conservation efforts, will give a short address to environmental groups in recognition of New Zealand Conservation Week.
The Prince and Duchess will fly back to Wellington shortly after 5.30pm.
