Human rights commissioners Dame Susan Devoy and Dr Jackie Blue are leaving the troubled agency as a management shake-up continues.
Disability Rights Commissioner Paula Tesoriero has been appointed acting head of the Human Rights Commission.
She is replacing Chief Human Rights Commissioner David Rutherford, who has decided to leave his role.
The changeover in leadership follows a critical review of the commission's internal processes and culture by retired judge Coral Shaw.
Blue, a former National MP, is not seeking reappointment after her term as a commissioner ends next month.