Within hours of treatment, with these so-called reversatrol analogues, the older cells started to divide, and had longer telomeres.
It is hoped the breakthrough could lead to anti-ageing therapies.
Key findings
The work of the team at Exeter University, supported by researchers at Brighton University, builds on their earlier findings which showed that a class of genes called splicing factors are progressively switched off as we age.
Lead researcher Professor Harries said: 'This is a first step in trying to make people live normal lifespans, but with health for their entire life.
"Our data suggests that using chemicals to switch back on the major class of genes that are switched off as we age might provide a means to restore function to old cells."
Dr Eva Latorre, research associate at the University of Exeter, who carried out the experiments, was surprised by the extent and rapidity of the changes in the cells.
She said: "When I saw some of the cells in the culture dish rejuvenating I couldn't believe it.
"These old cells were looking like young cells. It was like magic.
"I repeated the experiments several times and in each case the cells rejuvenated. I am very excited by the implications and potential for this research."
The research was published in the journal BMJ Cell Biology.
A DAILY GLASS OF WINE HELPS PROTECT YOUR HEART
Drinking a glass of wine or a bottle of beer a night could slash your risk of an early death by a fifth.
Moderate drinking - defined as up to seven drinks a week for women and 14 for men - significantly cuts the risk of dying from heart disease and other problems, a study has found.
The research, conducted among more than 300,000 Americans, directly contradicts official guidance published by the British chief medical officer.
Dame Sally Davies has stated there is 'no safe level' of drinking.
But while some evidence suggests drinking any amount may increase the risk of certain cancers, experts have said the benefits to the heart 'clearly outweigh' these risks, particularly among the elderly.
The research came from the University of Texas and Shandong University in China.