Regular intensive exercise can slow the heart to risky levels, scientists warn.
The heart rate naturally slows down as we get older. If we then take on too much exercise - such as running for ever longer distances or training for a marathon - it could cause us to collapse or find ourselves needing an electronic pacemaker.
Professor Mark Boyett of Manchester University said: "Exercise undoubtedly has enormous benefits for health but do things in moderation."
The heart researcher issued his advice after studying mice who were put through their paces on an uphill treadmill.
He found their heart rate fell over time, just like human runners. He also showed the slowing down was due to changes in the heart's own pacemaker - a clump of cells that makes the organ beat.